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Pregled bibliografske jedinice broj: 588608

Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin

Štimac, Vlado; Alihodžić, Sulejman; Lazarevski, Gorjana; Mutak, Stjepan; Marušić Ištuk, Zorica; Fajdetić, Andreja; Palej, Ivana; Čipčić Paljetak, Hana; Padovan, Jasna; Tavčar, Branka; Eraković Haber, Vesna
Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin // Journal of antibiotics, 62 (2009), 3; 133-144 doi:10.1038/ja.2009.1 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin

Autori
Štimac, Vlado ; Alihodžić, Sulejman ; Lazarevski, Gorjana ; Mutak, Stjepan ; Marušić Ištuk, Zorica ; Fajdetić, Andreja ; Palej, Ivana ; Čipčić Paljetak, Hana ; Padovan, Jasna ; Tavčar, Branka ; Eraković Haber, Vesna

Izvornik
Journal of antibiotics (0021-8820) 62 (2009), 3; 133-144

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azalide; acylide; antibacterial activity; pharmacokinetics; structure-activity relationship

Sažetak
A series of 4”-O-acyl derivatives of 8a-aza-8a- homoerythromycins A were synthesised and tested against Gram-positive and Gram-negative bacteria. Derivatives of 8a-aza-8a-homoerythromycin A have potent antibacterial activity against not only azithromycin-susceptible strains, but also efflux (M) and inducible macrolide-lincosamide- streptogramin (iMLSB) resistant Gram-positive pathogens. These compounds show moderate to high clearance and low oral bioavailability in preliminary in vivo pharmacokinetic studies in rat.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Andreja Fajdetić (autor)

Avatar Url Gorjana Lazarevski (autor)

Avatar Url Vesna Eraković Haber (autor)

Avatar Url Vlado Štimac (autor)

Avatar Url Sulejman Alihodžić (autor)

Avatar Url Jasna Padovan (autor)

Avatar Url Stjepan Mutak (autor)

Avatar Url Branka Tavčar (autor)

Avatar Url Zorica Marušić Ištuk (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com www.nature.com

Citiraj ovu publikaciju:

Štimac, Vlado; Alihodžić, Sulejman; Lazarevski, Gorjana; Mutak, Stjepan; Marušić Ištuk, Zorica; Fajdetić, Andreja; Palej, Ivana; Čipčić Paljetak, Hana; Padovan, Jasna; Tavčar, Branka; Eraković Haber, Vesna
Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin // Journal of antibiotics, 62 (2009), 3; 133-144 doi:10.1038/ja.2009.1 (međunarodna recenzija, članak, znanstveni)
Štimac, V., Alihodžić, S., Lazarevski, G., Mutak, S., Marušić Ištuk, Z., Fajdetić, A., Palej, I., Čipčić Paljetak, H., Padovan, J., Tavčar, B. & Eraković Haber, V. (2009) Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin. Journal of antibiotics, 62 (3), 133-144 doi:10.1038/ja.2009.1.
@article{article, author = {\v{S}timac, Vlado and Alihod\v{z}i\'{c}, Sulejman and Lazarevski, Gorjana and Mutak, Stjepan and Maru\v{s}i\'{c} I\v{s}tuk, Zorica and Fajdeti\'{c}, Andreja and Palej, Ivana and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Tav\v{c}ar, Branka and Erakovi\'{c} Haber, Vesna}, year = {2009}, pages = {133-144}, DOI = {10.1038/ja.2009.1}, keywords = {azalide, acylide, antibacterial activity, pharmacokinetics, structure-activity relationship}, journal = {Journal of antibiotics}, doi = {10.1038/ja.2009.1}, volume = {62}, number = {3}, issn = {0021-8820}, title = {Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin}, keyword = {azalide, acylide, antibacterial activity, pharmacokinetics, structure-activity relationship} }
@article{article, author = {\v{S}timac, Vlado and Alihod\v{z}i\'{c}, Sulejman and Lazarevski, Gorjana and Mutak, Stjepan and Maru\v{s}i\'{c} I\v{s}tuk, Zorica and Fajdeti\'{c}, Andreja and Palej, Ivana and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Tav\v{c}ar, Branka and Erakovi\'{c} Haber, Vesna}, year = {2009}, pages = {133-144}, DOI = {10.1038/ja.2009.1}, keywords = {azalide, acylide, antibacterial activity, pharmacokinetics, structure-activity relationship}, journal = {Journal of antibiotics}, doi = {10.1038/ja.2009.1}, volume = {62}, number = {3}, issn = {0021-8820}, title = {Synthesis and Biological Properties of 4''-O-Acyl Derivatives of 8a-Aza-8a-homoerythromycin}, keyword = {azalide, acylide, antibacterial activity, pharmacokinetics, structure-activity relationship} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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