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Pregled bibliografske jedinice broj: 588189

The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients

Nadalin, Sergej; Giacometti, Jasminka; Jonovska, Suzana; Tomljanović, Draško; Buretić-Tomljanović, Alena
The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients // Prostaglandins leukotrienes and essential fatty acids, 88 (2013), 2; 185-190 doi:10.1016/j.plefa.2012.11.005 (međunarodna recenzija, članak, znanstveni)

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Naslov
The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients

Autori
Nadalin, Sergej ; Giacometti, Jasminka ; Jonovska, Suzana ; Tomljanović, Draško ; Buretić-Tomljanović, Alena

Izvornik
Prostaglandins leukotrienes and essential fatty acids (0952-3278) 88 (2013), 2; 185-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Schizophrenia; Niacin skin flush test; PLA2G4A polymorphism; PTGS2 polymorphism; Red blood cell membranes; Essential polyunsaturated fatty acids

Sažetak
We investigated the etiology of the attenuated niacin skin flush response in schizophrenia patients. Skin response to topical niacin of 0.1M, 0.01M, 0.001M and 0.0001M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of the PLA2G4A), and rs689466 of the prostaglandin synthase 2 (PTGS2). We further tested the possible correlation between niacin response and fatty acid (FA) content of red blood cells (RBCs). We detected statistically significant but weak impact of both polymorphisms on niacin flush response in schizophrenia patients. The dosage of the G alleles of both polymorphisms was associated with higher VNR values, although each polymorphic variant accounted for only 1% of the overall flush response variability. Regarding FA content, both n-3 and n-6 polyunsaturated FAs (PUFAs) were significantly reduced in the patient group, but an association with niacin sensitivity was not detected.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0982522-0369 - Genetika metabolizma fosfolipida u shizofreniji (Buretić-Tomljanović, Alena, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Jasminka Giacometti (autor)

Avatar Url Suzana Jonovska (autor)

Avatar Url Alena Buretić-Tomljanović (autor)

Avatar Url Sergej Nadalin (autor)

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Nadalin, Sergej; Giacometti, Jasminka; Jonovska, Suzana; Tomljanović, Draško; Buretić-Tomljanović, Alena
The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients // Prostaglandins leukotrienes and essential fatty acids, 88 (2013), 2; 185-190 doi:10.1016/j.plefa.2012.11.005 (međunarodna recenzija, članak, znanstveni)
Nadalin, S., Giacometti, J., Jonovska, S., Tomljanović, D. & Buretić-Tomljanović, A. (2013) The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients. Prostaglandins leukotrienes and essential fatty acids, 88 (2), 185-190 doi:10.1016/j.plefa.2012.11.005.
@article{article, author = {Nadalin, Sergej and Giacometti, Jasminka and Jonovska, Suzana and Tomljanovi\'{c}, Dra\v{s}ko and Bureti\'{c}-Tomljanovi\'{c}, Alena}, year = {2013}, pages = {185-190}, DOI = {10.1016/j.plefa.2012.11.005}, keywords = {Schizophrenia, Niacin skin flush test, PLA2G4A polymorphism, PTGS2 polymorphism, Red blood cell membranes, Essential polyunsaturated fatty acids}, journal = {Prostaglandins leukotrienes and essential fatty acids}, doi = {10.1016/j.plefa.2012.11.005}, volume = {88}, number = {2}, issn = {0952-3278}, title = {The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients}, keyword = {Schizophrenia, Niacin skin flush test, PLA2G4A polymorphism, PTGS2 polymorphism, Red blood cell membranes, Essential polyunsaturated fatty acids} }
@article{article, author = {Nadalin, Sergej and Giacometti, Jasminka and Jonovska, Suzana and Tomljanovi\'{c}, Dra\v{s}ko and Bureti\'{c}-Tomljanovi\'{c}, Alena}, year = {2013}, pages = {185-190}, DOI = {10.1016/j.plefa.2012.11.005}, keywords = {Schizophrenia, Niacin skin flush test, PLA2G4A polymorphism, PTGS2 polymorphism, Red blood cell membranes, Essential polyunsaturated fatty acids}, journal = {Prostaglandins leukotrienes and essential fatty acids}, doi = {10.1016/j.plefa.2012.11.005}, volume = {88}, number = {2}, issn = {0952-3278}, title = {The impact of PLA2G4A and PTGS2 gene polymorphisms, and red blood cell PUFAs deficit on niacin skin flush response in schizophrenia patients}, keyword = {Schizophrenia, Niacin skin flush test, PLA2G4A polymorphism, PTGS2 polymorphism, Red blood cell membranes, Essential polyunsaturated fatty acids} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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