Naslov
STRUCTURAL INVESTIGATIONS OF AROYLHYDRAZONES

Autori
Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract / Radu Oprean - Cluj - Napoca, 2012, 56-56

Skup
12th INTERNATIONAL SYMPOSIUM AND SUMMER SCHOOL ON BIOANALYSIS

Mjesto i datum
Cluj-Napoca, Rumunjska, 04.07.2012. - 14.07.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
aroylhydrazones; keto-enol tautomery; E-Z isomerisation

Sažetak
Aroylhydrazones have been intensively investigated in resent years due to their versatile properties and applications. Many compounds of this type are biologically active as anticancer, antibacterial and antimicrobial agents. Hydrazones derived from isonicotinoyl hydrazide have been investigated as potential drugs for treatment of iron-overload associated diseases. In addition, this class of iron chelators showed remarkable antimalarial activity. Recent studies have shown that nicotinic acid hydrazones could be considered as a novel pharmacophore in the design of anticonvulsant drugs. Aroylhydrazones can be involved in keto-enol tautomeric interconversion. Tautomeric equilibrium can involve hydrazide part of the molecule, but also and aldehyde moiety if the hydroxyl group is situated in ortho position with respect to the C=N double bond. Apart from tautomeric interconversion, E–Z isomerisation of hydrazones due to solvent effect, pH value or UV irradiation can also occur. Different tautomeric and isomeric forms have different spectral properties and can be distinguished according to their IR, UV-Vis and NMR spectra. Since E/Z isomers can have diverse chelating properties as well as pharmacodynamic activities, the study of such equilibrium is relevant not only from theoretical point of view, but for further development of aroylhydrazones as potential drug candidates. In this lecture the results of structural investigations of aroylhydrazones derived from nicotinic acid hydrazide and various aldehydes in solid state and in solution by different spectrometric techniques will be given. In addition, the tautomeric interconversion upon complexation of transition-metal cations will be discussed as well.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA