Naslov
Influence of Preoperative Oral Feeding on Stress Response after Resection for Colon Cancer

Autori
Zelić, Marko ; Štimac, Davor ; Mendrila, Davor ; Sotošek Tokmadžić, Vlatka ; Fišić, Elizabeta ; Uravić, Miljenko ; Šustić, Alan

Izvornik
Hepato-gastroenterology (0172-6390) 59 (2012), 117; 1385-1389

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colon cancer; preoperative feeding; perioperative stress

Sažetak
Preoperative management involves patients fasting from midnight on the evening prior to surgery. Fasting period is often long enough to change the metabolic condition of the patient which increases perioperative stress response. That could have a detrimental effect on clinical outcome. The aim of the present study was to investigate the possible effects of carbohydrate-rich beverage on stress response after colon resection. Randomized and double blinded study included 40 patients with colon, upper rectal or rectosigmoid cancer. Investigated group received a carbohydrate-rich beverage the day before and two hours before surgery. In the control group patients were in the standard preoperative regime: nothing by mouth from the evening prior to operation. Peripheral blood was sampled 24h before surgery, at the day of the surgery, and 6, 24 and 48h postoperatively. Results: Colonic resection in both groups caused a significant increase in serum interleukin 6 (IL-6) levels 6, 24 and 48h after the operation. Increase was more evident and statistically significant in the group with fasting protocol. More significant increase of interleukin 10 (IL-10) occurred in patients who received preoperative nutrition. Smaller increase in IL-6 and higher in IL- 10 are indicators of reduced perioperative stress.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA