Naslov
Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

Autori
Buljan, Melita ; Nemet, Damir ; Golubić- Čepulić, Branka ; Bićanić, Goran ; Tripković, Branko ; Delimar, Domagoj

Izvornik
International orthopaedics (0341-2695) 36 (2011), 4; 703-709

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
autologous blood donation ; hip arthroplasty ; human recombinant erythropoieti ; erythropoietin ; blood transfusion ; dose regimen

Sažetak
Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA). Prospective randomised trials in which erythropoietin 15, 000 IU was administered intravenously twice a week or 30, 000 IU once a week (total 90, 000 IU) combined with ferrous II sulphate (Ferro- Gradumet 2) orally and compared with Ferro-Gradumet 2 alone. RESULTS: Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients. We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA