Naslov
Condensed DNA toroids in bacteriophage capsids

Autori
Šiber, Antonio

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
From Solid State To BioPhysics VI / - , 2012

Skup
From Solid State To BioPhysics VI

Mjesto i datum
Cavtat, Hrvatska, 09.06.2012. - 15.06.2012

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Nije recenziran

Ključne riječi
virus; DNA; elasticity; surface tension; condensation

Sažetak
The shape of condensed DNA toroids is determined by the interplay of elastic energy of wound DNA and the surface energy of the DNA strands exposed on the toroid surface [1]. The hugely complicated microscopic situation with myriad of molecular interactions can be reduced to a continuum model containing only two parameters: the DNA persistence length and the »surface tension« of the DNA. Such a model predicts DNA toroid shapes which depend on a single, combined parameter mixing the elastic and surface energy contributions of the free energy. I will show how the model can be extended to study the formation of a condensed DNA toroid within a bacteriophage capsid. This involves adding a third (second) parameter to the model which signifies the effective DNA-capsid interaction. The predictions of the extended model are shown to compare favorably with experimental data [2]. The effective DNA-capsid interaction is found to depend on the condensation agent (PEG vs spermine). [1] J. Ubbink and T. Odijk, Deformation of toroidal DNA condensates under surface stress, Europhys. Lett. 33 (1996). [2] Amélie Leforestier, Antonio Šiber, Françoise Livolant and Rudolf Podgornik, Biophys. J. 100, 2209 (2011).

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA