Naslov
Synthesis and biological evaluation of the novel purine and pyrimidine nucleoside analogues containing 2,3-epoxypropyl, 3-amino-2-hydroxypropyl or 2,3-epoxypropyl ether moieties

Autori
Raić-Malić, Silvana ; Grdiša, Mira ; Pavelić, Krešimir ; Mintas, Mladen

Izvornik
European journal of medicinal chemistry (0223-5234) 34 (1999), 5; 405-413

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
purine and pyrimidine nucleoside analogues ; 1H and 13C NMR ; 2D homo- and hetero-nuclear correlation spectroscopy ; antitumour activity ; antiviral activity

Sažetak
The novel purine and pyrimidine nucleoside analogues possessing a 2, 3-epoxypropyl (2a-2c and 8a-8c), 2, 3-epoxypropyl ether (3), or 3-amino-2-hidroxypropyl (4a-6c and 9a-9c) moiety bonded at either N-9 of the C-6 substituted purine ring or N-1 and N-3 of the pyrimidine ring, were prepared and evaluated on their antitumour and antiviral activities. Compounds 3, 6b, 8b and 8c showed marked inhibition of growth of human tumour cell lines (MiaPaCa2 and Raji), whilst the inhibitory effect of 6b was greated against Raji cell than to the MiaPaCa2 ones. No specific activity of compounds 2a-3, 4a-6c and 9a-9c against HSV and VZV was detected. The compounds 6b was highly active against the replication of HIV 1 (IIIB), while 2a-2c and 8a-8c were inactive.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA