Naslov
Roles of RecQ, UvrD and HelD helicases in the RecF recombination pathway of Escherichia coli

Autori
Buljubašić, Maja ; Repar, Jelena ; Zahradka, Ksenija ; Đermić, Damir ; Zahradka, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 3rd Congress of Croatian Geneticists with international participation / Franekić, Jasna ; Garaj-Vrhovac, Verica - Zagreb : Hrvatsko genetičko društvo, 2012, 11-11

ISBN
978-953-57128-0-0

Skup
3rd Congress of Croatian Geneticists with international participation

Mjesto i datum
Krk, Hrvatska, 13.05.2012. - 16.05.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
DNA repair; Escherichia coli; helicases; nucleases; recombination; RecF pathway

Sažetak
DNA helicases play an important role during initiation of homologous recombination by generating recombinogenic 3’ single-stranded DNA ends. Recombination in recBCD sbcB sbcC(D) mutants of Escherichia coli proceeds via RecF pathway, which is thought to require RecQ, UvrD and HelD helicases at its initial stage. Previous studies suggested that depletion of all three helicases totally abolishes the RecF pathway. The present study (re)examines the roles of these helicases in transductional recombination, and in recombinational repair of UV-induced DNA damage in the RecF pathway.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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