Naslov
Fidelity of DNA repair and genome stability in Deinococcus radiodurans

Autori
Repar, Jelena ; Cvjetan, Svjetlana ; Slade, Dea ; Radman, Miroslav ; Zahradka, Davor ; Zahradka, Ksenija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 3rd Congress of Croatian Geneticists with international participation / Franekić, Jasna ; Garaj-Vrhovac, Verica - Zagreb : Hrvatsko genetičko društvo, 2012, 10-10

ISBN
978-953-57128-0-0

Skup
3rd Congress of Croatian Geneticists with international participation

Mjesto i datum
Krk, Hrvatska, 13.05.2012. - 16.05.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Deinococcus radiodurans; DNA repair; gamma-irradiation; genome rearrangements

Sažetak
Deinococcus radiodurans, an extremophile bacterium, resists extreme conditions of life, such as excessive desiccation and exposures to high doses of radiation or toxic chemicals. These conditions are known to severely damage the cellular genome by introducing double-strand DNA breaks – the most severe form of chromosomal damage. Genome reassembly in heavily irradiated D. radiodurans is considered to be an error-free process since no genome rearrangements were detected after post-irradiation repair. Here, we describe for the first time conditions that impair the remarkable fidelity of DNA repair in this bacterium.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA