Naslov
ENOS VNTR polymorphism and hypertension in oldest- olds (85+ years)

Autori
Zajc Petranović, Matea ; Tomas, Željka ; Krajačić, Petra ; Škarić-Jurić, Tatjana ; Miličić, Jasna ; Tomek-Roksandić, Spomenka ; Smolej Narančić, Nina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd congress of Croatian geneticists with international participation : Book of abstracts / Franekić, Jasna ; Garaj-Vrhovac, Verica - Zagreb : Hrvatsko genetičko društvo, 2012, 118-118

ISBN
978-953-57128-0-0

Skup
Congress of Croatian geneticists with international participation (3 ; 2012)

Mjesto i datum
Krk, Hrvatska, 13.05.2012. - 16.05.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
eNOS gene polymorphisms ; Essential hypertension ; Intron 4 a/b VNTR ; Longevity ; Croatia

Sažetak
Nitric oxide (NO) plays a major role in the regulation of blood vessel tone. Production of NO can be influenced by polymorphisms of the endothelial NO synthase (eNOS) gene, which is proven to be associated with the pathogenesis of essential hypertension (EHT). Essential hypertension, a major public health problem, has been estimated to have 30 – 40% of the interindividual variability in blood pressure (BP) levels due to genetic differencies. Numerous studies have shown that elevated blood pressure is one of the leading risk factors for morbidity and total mortality. However, only a few have found the association between eNOS variable number of tandem repeats (VNTR) intron 4a/b and hypertension, and even less tested this association in elderly cohorts. Additionally, there are no data on relation of eNOS VNTR and longevity. This study, performed among the oldest-olds of Croatia (85-101 yrs ; mean=88.32 yrs ; N=320, 82 M/238 F ; 44.3% with EHT), provides information on the eNOS VNTR polymorphism, EHT and several other cardiovascular disease (CVD) phenotypes as well as a possible relation of this polymorhism and longevity. For comparison of association between eNOS polymorphism and longevity we used previously reported frequencies for the general population of Croatia (N=51, 25 M/26 F) aged 16-81 yrs. We found no genotype association with hypertension or with dislypidemia and CVD phenotypes. Compared to the previously reported data on general population, no relationship emerged that might support the thesis that any of the eNOS VNTR genotypes contributes to longevity. We suggest that further research of nitric oxide - hypertension relation should be directed towards broader spectrum of eNOS polymorphisms involved in NO synthesis and metabolism rather than focusing on eNOS VNTR polymorphisms as the main factor.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA