Naslov
Effectiveness of quetiapine treatment in patients with schizophrenia who didn't respond well to previous treatment

Autori
Kozumplik, Oliver ; Uzun, Suzana ; Mimica, Ninoslav ; Folnegović-Šmalc, Vera ; Jukić, Vlado

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Finale Programme and Abstract Book. U: Periodicum biologorum 106 (Suppl.1) / Vitale, Branko - Zagreb, 2004, 124-124

Skup
Fourth Croatian Congress of Pharmacology with international participation

Mjesto i datum
Split, Hrvatska, 15.09.2004. - 18.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
efikasnost ; kvetiapin ; shizofrenija
(effectiveness ; quetiapine ; schizophrenia)

Sažetak
Introduction: The atypical antipsychotic quetiapine has efficacy against the positive, negative, affective and cognitive symptoms of schizophrenia. The efficacy of quetiapine in the treatment of acute schizophrenia was demonstrated in controlled trials in vvhich quetiapine was shown to be both superior to placebo and associated with clinically meaningful improvement. Regarding efficacy against positive symptoms examination of the Brief Psychiatric Rating Scale (BPRS) positive symptom cluster in the clinical studies have shown that quetiapine treatment was associated with a greater improvement in psychopathology than placebo. Compared to placebo, clinical studies have also showned improvement by quetiapine regarding negative symptoms as measured by the Scale for the Assessment of Negative Symptoms (SANS). Quetiapine was shown to improve symptoms in patients with schizophrenia who had partiall responded to conventional antipsychotics. The aim was to assess the effectiveness of quetiapine treatment in the open-label, non- comparative, 12-week study (with flexible doses of quetiapine in patients vvith schizophrenia who had inadequate response to or intolerance of their previous antipsychotic therapy. Patients and Methods: Sixty schizophrenic patients according to DSM-IV diagnostic criteria were switched to quetiapine during hospitalisation in Vrapče Psvchiatric Hospital in the period from March to July 2003. Patients were switched due to inadequate response to or intolerance of their previous antipsychotic therapy. The Clinical Global Impression (CGI) and Positive and Negative Syndrome Scale (PANSS) vvere used in order to assess effectiveness of treatment with quetiapine. Quetiapine was introduced at dose of 50 mg on day one, follovved by 100 mg, 200 mg and 300 mg on days 2, 3, and 4. After day 4, the daily dosage was between 300 mg and 1200 mg, depending on the clinical presentation. The patients were assessed prior to initiation of quetiapine treatment, after six weeks and after twelve weeks of continuous therapy with quetiapine. Statistical significance was set to a value of p.05. Results: After twelve weeks of continuous therapy vvith quetiapine, PANSS total score significantly decreased in the group of patients who were switched to quetiapine because of inadequate response to previous antipsychotic therapy (p.05). The mean CGI severity score for ali patients improved from 3.8 (»moderately ili«) to 2.9 (»mildly ili«). Conclusion: Administration of quetiapine was clinically beneficial for the patients with schizophrenia who had inadequate response to or intolerance of their previous antipsychotic therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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