Pregled bibliografske jedinice broj: 577291
Statins and cancer : Current and future prospects
Statins and cancer : Current and future prospects // Cancer letters, 324 (2012), 1; 1-12 doi:10.1016/j.canlet.2012.04.011 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 577291 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Statins and cancer : Current and future prospects
Autori
Osmak, Maja
Izvornik
Cancer letters (0304-3835) 324
(2012), 1;
1-12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
statins; cancer prevention; cancer treatment
Sažetak
Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects beyond cholesterol reduction, including anticancer activity. This review presents the effects of statins in vitro and their possible molecular anticancer mechanisms and critically discusses the data regarding the role of statins in cancer prevention. Finally, this review focuses on the use of statins combined with other chemotherapeutics to increase the effectiveness of cancer treatments. Despite rare and inconclusive clinical data, the preclinical results strongly suggest that such combined treatment could be a promising new strategy for the treatment of certain tumor types.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Osmak, Maja, MZOS ) ( CroRIS)
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Ambriović Ristov, Andreja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Maja Osmak
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
