Naslov
Prediction of structural and physicochemical properties of DNA with special regard to curvature and bendability

Autori
Vlahoviček, Kristian

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Prirodoslovno-matematički fakultet

Mjesto
Zagreb

Datum
24.02

Godina
2000

Stranica
132

Mentor
Pongor, Sándor; Kamenar, Boris

Ključne riječi
bendability; computer program; curvature; genomic DNA; Internet server; molecular modeling prediction

Sažetak
The increasing number of sequenced genomes requires additional methods for analysis of genomic sequences. In addition to genetic information, DNA molecule encodes conformational signals like curvature and bendability. These local phenomena are sequence-dependent and are known to influence processes such as gene regulation, genome packaging and DNA replication. Curvature and bendability of a DNA segment can be predicted using computer method based on structural or physical DNA parameters. This work presents a set of computer programs for prediction and visualization of curvature and other physicochemical properties of genomic DNA, as well as molecular modeling of short nucleotide sequences. These programs were used for analysis of selected genomes and model building of a set of Zea mays promoter regions. Results, presented id the form of a 'genome atlas', indicate differences in curvature distributions between coding and non-coding regions of genomes. An Internet server is set up for curvature prediction and generation of 3D models from DNA sequences at http://www.icgeb.trieste.it/dna

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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