Pregled bibliografske jedinice broj: 576663
Cocrystals of Lamotrigine Based on Coformers Involving Carbonyl Group Discovered by Hot-Stage Microscopy and DSC Screening
Cocrystals of Lamotrigine Based on Coformers Involving Carbonyl Group Discovered by Hot-Stage Microscopy and DSC Screening // Crystal growth & design, 12 (2012), 4; 1847-1858 doi:10.1021/cg201426z (međunarodna recenzija, članak, znanstveni)
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Naslov
Cocrystals of Lamotrigine Based on Coformers Involving Carbonyl Group Discovered by Hot-Stage Microscopy and DSC Screening
Autori
Lekšić, Edislav ; Pavlović, Gordana ; Meštrović, Ernest
Izvornik
Crystal growth & design (1528-7483) 12
(2012), 4;
1847-1858
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lamotrigine cocrystals; hot-stage thermomicroscopy; differential scanning calorimetry; crystal engineering; supramolecular synthons
Sažetak
Four novel lamotrigine cocrystals, namely, 1:1 lamotrigine:phthalimide (1), 1:1:1 lamotrigine:pyromellitic diimide:DMF (2), 2:1:0.64 lamotrigine:caffeine:3-pentanone (3), and 1:1 lamotrigine:isophthaldehyde (4), were discovered using a combined hot-stage thermomicroscopy and differential-scanning calorimetry screening technique. The utilized cocrystal screening method is rapid, requires the use of small amounts of material, and is highly suitable for compounds that are prone to solvate formation. The structurally characterized cocrystals were prepared in an attempt to develop lamotrigine cocrystals based on cocrystal formers involving carbonyl and amide functional groups. The prepared cocrystals are sustained by N−H(amide)···N(pyridyl), N−H(amino)···O(amide), and N−H(amino)···O(carbonyl) hydrogen bonds.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-1191344-2943 - Protein-ligand međudjelovanja na atomnoj razini (Luić, Marija, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
