Naslov
Microvascular reactivity in subcutaneous and visceral fat tissue in human obesity

Autori
Grizelj, Ivana ; Čavka, Ana ; Bian, Jing-Tan ; Drenjančević, Ines ; Phillips, Shane A

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The FASEB Journal (Meeting Abstract Supplement) 2012 ; 26 / - Miami (FL) : Bethesda, MD : Federation of American Societies for Experimental Biology, 2012

Skup
Experimental Biology 2012

Mjesto i datum
San Diego (CA), Sjedinjene Američke Države, 21.04.2012. - 25.04.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Microvascular Reactivity; Obesity
(microvascular reactivity; obesity)

Sažetak
Microvascular dysfunction contributes to cardiovascular disease risk during obesity. Prior data suggest that visceral adipose tissue (VAT) is associated to cardiometabolic risk factors and endothelial dysfunction compared subcutaneous adipose tissue (SAT). The aim of this study was to determine flow induced dilation (FID) in human VAT and SAT resistance arteries. We hypothesized that microvascular FID is impaired in VAT compared to SAT during obesity. Microvessels were obtained from VAT and SAT biopsies in lean (LN ; BMI<27) and during bariatric surgery (OB ; BMI>48). Isolated vessels were cannulated for vascular reactivity to flow (pressure gradient cmH2O, 20, 40, 60, 100) in the absence and presence of the NOS inhibitor L- NAME (10–4 M). Dilations to papaverine (10–4M) were determined in each vessel. FID was reduced in VAT (at 60, 59±7%, p<0.05) compared to SAT (at 60, 100±10%). Interestingly, FID was increased in SAT but not VAT from OB compared to LN subjects. There was no change in maximal dilation to papaverine between groups. In addition, there was no effect of L-NAME on FID in SAT of OB and LN. However, L- NAME reduced FID in VAT of OB (at 60, 36±8% ; p<0.05) vs. baseline. These data suggest that 1) FID is reduced in visceral compared to subcutaneous fat of obese patients and 2) NO mediates FID in microvessels from visceral but not subcutaneous adipose during obesity. NIH (K23HL085614, R01HL095701), UKF (87/11, 88/11).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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