Naslov
Examination of seasonal difference in serum interleukin-17 and interleukin-5 concentrations in ragweed-sensitized children

Autori
Špehar, Mirjana ; Zovko, Vlasta ; Šegulja, Dragana ; Zrinski Topić, Renata ; Dodig, Slavica

Izvornik
Aerobiologia (Bologna) (0393-5965) 28 (2012), 2; 99-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Allergy ; Eosinophil cationic protein ; Eosinophil ; IL-5 ; IL-17 ; Ragweed

Sažetak
Dysregulation of inflammatory mediators is characteristic for chronic inflammation in allergy. The aim was to determine the values of serum IL-17 and IL-5 in ragweed-sensitized children. The study included children analyzed during the ragweed pollen season compared to children analyzed out of season. Serum total IgE, specific IgE, and eosinophil cationic protein (ECP) were determined by fluoroimmunoassay while the concentrations of IL-5 and IL-17 were determined by flow cytometry. Patients evaluated during the pollen season, have higher values of total and specific IgE, eosinophil and neutrophil count than patients studied outside the pollen season. There was no statistically significant seasonal and out of season differences for the concentration of IL-17, IL-5, and ECP. Natural exposure to ragweed pollen allergen was not crucial for the induction of increased IL-17 and IL-5 synthesis, and factors other than allergen exposure should be investigated, especially in longitudinal studies of patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA