Pregled bibliografske jedinice broj: 57613
Association between equine leukocyte antigens and allergen-specific serum immunoglobulin E levels in Lipizzan horses.
Association between equine leukocyte antigens and allergen-specific serum immunoglobulin E levels in Lipizzan horses. // 27th International Conference on Animal Genetics, Conference Abstract CD-ROM.
Lahti: International Society for Animal Genetics, 2000. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 57613 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Association between equine leukocyte antigens and allergen-specific serum immunoglobulin E levels in Lipizzan horses.
Autori
Eder, C. ; Curik Ino ; Brem G. ; Lazary, S. ; Sölkner, J. ; Marti, E.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
27th International Conference on Animal Genetics, Conference Abstract CD-ROM.
/ - Lahti : International Society for Animal Genetics, 2000
Skup
27th International Conference on Animal Genetics, ISAG 2000.
Mjesto i datum
Minneapolis (MN), Sjedinjene Američke Države, 22.07.2000. - 26.07.2000
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Sažetak
IgE plays a key role in the pathogenesis of atopy, a subgroup of allergic diseases with a genetic predisposition to generate IgE against innocuous environmental allergens. Additionally to genetic factors that influence a general predisposition for high IgE responses, the MHC influences the ability to produce specific IgE against small, well-defined allergens. The aim of the presented study was to investigate whether an association between ELA class I alleles and specific serum IgE levels can be demonstrated in the horse. For that purpose, IgE levels against Alternaria alternata (Alt a) and Aspergillus fumigatus (Asp f ) extracts and against recombinant (r) Alt a 1 and rAsp f 7 and 8 were determined in sera from 427 Lipizzans from six studs. Serological ELA-typing was performed according to Lazary et al. (1988, Animal Genetics 19, 447). Effects of stud, sex and age on allergen-specific IgE levels were included in the gene substitution models used to test effects of ELA class I alleles on specific IgE levels. A significant (p<0.05) positive association between ELA-A1 and rAsp f 7 specific IgE, and significant (p<0.01) negative associations between ELA-A8 and rAlt a 1, rAsp f 7 and rAsp f 8 specific IgE were demonstrated. Furthermore, ELA-A1 was associated with higher IgE levels against Asp f extract (p<0.05) and ELA-A14 with lower IgE titres against Alt a and Asp f extracts (p<0.05). Further studies like segregation studies in families and determination of ELA class II alleles are needed to better characterise the MHC associations identified in this investigation.
Izvorni jezik
Engleski
Znanstvena područja
Šumarstvo
