Naslov
Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis

Autori
Brnić, Dragan ; Stevanović, Vladimir ; Cochet, Marielle ; Agier, Cécilia ; Richardson, Jennifer ; Montero-Menei, Claudia N. ; Milhavet, Ollivier ; Eloit, Marc ; Coulpier, Muriel

Izvornik
Journal of virology (0022-538X) 86 (2012), 5; 2512-2522

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Borna Disease Virus; Human Neural Progenitor Cells; Neurogenesis

Sažetak
Understanding the complex mechanisms by which infectious agents can disrupt behavior represents a major challenge. The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. Because BDV induces neurodegeneration in brain areas that are still undergoing maturation at the time of infection, we tested the hypothesis that BDV interferes with neurogenesis. We showed that human neural stem/progenitor cells are highly permissive to BDV, although infection does not alter their survival or undifferentiated phenotype. In contrast, upon the induction of differentiation, BDV is capable of severely impairing neurogenesis by interfering with the survival of newly generated neurons. Such impair- ment was specific to neurogenesis, since astrogliogenesis was unaltered. In conclusion, we demonstrate a new mechanism by which BDV might impair neural function and brain plasticity in infected individuals. These results may contribute to a better understanding of behavioral disorders associated with BDV infection.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA