Naslov
Microarray expression analysis of primary Dupuytren´s contracture cells

Autori
Kraljević Pavelić, Sandra ; Ratkaj, Ivana

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Dupuytren's disease and related hyperproliferative disorders

Urednik/ci
Eaton C SM, Bayat A, Gabbiani G, Werker P, Wach W

Izdavač
Springer

Grad
Berlin : Heidelberg

Godina
2012

Raspon stranica
109-113

ISBN
978-3-642-22696-0

Ključne riječi
Dupuytren's disease, microarray

Sažetak
In our research we studied gene expression in primary cell cultures cultured from affected palmar fascia in comparison with patient matched non-affected fascia by use of Affymetrix whole-genome microarray platform. Differentially expressed genes identified in our study might be responsible for pathological changes and rise of typical Dupuytren’s contracture .symptoms. RT-PCR method has been employed for validation of microarray results. Expression of ten genes correlated with obtained microarray data. Especially, up-deregulation of six genes involved in signal transduction pathways that might be responsible for changes in the extracellular matrix and development of palmar contracture have been observed. Our results complement current knowledge on gene expression patterns of Dupuytren’s contracture.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA