Pregled bibliografske jedinice broj: 572365
Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA
Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA // Acta chimica Slovenica, 59 (2012), 3; 464-472 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 572365 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of the peptide-based phenanthridine- nucleobase conjugates and study of their interactions with ds-DNA
Autori
Dukši, Marko ; Baretić, Domagoj ; Piantanida, Ivo
Izvornik
Acta chimica Slovenica (1318-0207) 59
(2012), 3;
464-472
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
phenanthridine-nucleobase conjugate; DNA; CD; fluorescence
Sažetak
Series of novel peptide-bridged phenanthridine- nucleobase conjugates were prepared by solid phase peptide synthesis, which allowed easy and fast tuning of structure properties. Compounds were fully characterized in aqueous medium, pointing out to intramolecularly stacked structures. The stacked phenanthridine-thymine-phenanthridine system revealed characteristic excimeric fluorescence band and very specific CD spectrum. Studied compounds interact with double stranded DNA by intercalation, whereby binding is to minor extent influenced by attached thymine and amino- acid sequence of the peptide backbone.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Napomena
Memorial Issue : Celebrating the 70th birthday of Professor Dr. Gorazd Vesnaver.
POVEZANOST RADA
Projekti:
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Ivo Piantanida
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
