Naslov
Biological repair of thyroid cartilage defects by osteogenic protein-1 (BMP-7) and different carriers in dog

Autori
Katic, Vladimir ; Majstorovic, Lidija ; Maticic, Drazen ; Pirkic, Boris ; Yin, Samuel ; Kos, Josip ; Martinovic, Snjezana ; Vukicevic, Slobodan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Conference on Bone Morphogenetic Proteins / Hari Reddi A. - Sacramento (CA) : Center for tissue regeneration and repair. Univ. of Ca, Davis, 2000

Skup
International Conference Bone Morphogenetic Proteins 2000

Mjesto i datum
Tahoe City (CA), Sjedinjene Američke Države, 07.06.2000. - 11.06.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Bone morphogenetic protein; thyroid cartilage; larynx recontruction

Sažetak
We have recently shown that OP-1 bound to thyroid alograft regenerated large thyroid cartilage defects by inducing new bone, cartilage and ligament-like structures (Katic et al, Growth Factors 16, 1999). In the present study we tested the efficacy of OP-1 in regeneration of thyroid cartilage defects (2cm2) in dog using different carriers. OP-1 with a carrier was applied to the defect area and maintained between perichondrial layers adjacent to the defect. The treatment groups (n=4) were as follows:I/OP-1/CMC device, II/OP-1/CMC/blood and III/OP-1/Helistat sponge. Dogs were killed four months following surgery. Each larynx was removed, carefully dissected and three-dimensinal reconstruction of defect area was performed on serial sections. The results revealed that thyroid defects in group I healed almost completely by newly formed bone and ligament. New bone was well connected to both cartilage ends. This is the first evidence that CMC can serve as a carrier for recombinant BMP. Defects in group II and III also healed completely by bone and ligament tissue in a very remodelinf phase, but no apparent cartilage was evident. This study suggests that in the presence of different carriers, where tissue processing is not controlled by slow release of morphogen and guidance by an extracellular matrix carrier, osteogenesis prevails above chondrogenesis in regenerating thyroid cartilage defects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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