Naslov
Photochemical formation and investigation of antiproliferative effect of adamantylnaphthalene quinone methides

Autori
Basarić, Nikola ; Veljković, Jelena ; Mlinarić-Majerski, Kata ; Uzelac, Lidija ; Kralj, Marijeta ; Wan, Peter

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Central European Conference on Photochemistry/CECP 2012/Bad Hofgastein, Austria / - , 2012

Skup
Central European Conference on Photochemistry/CECP 2012/Bad Hofgastein, Austria

Mjesto i datum
Bad Hofgastein, Austrija, 05.02.2012. - 09.02.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antiproliferative effect; hydroxyadamantyl; aminoadamantyl; quinone methides;

Sažetak
Recently we have become interested in photochemical formation of sterically congested quinone methides (QM) [1]. We have found out that introduction of a bulky adamantyl substituent at the methylene position of QMs hinders attack of nucleophiles resulting in longer-lived species and selectivity towards N-nucleophiles. In continuation of that research we studied photochemistry of QMs formed from adamantyl derivatives of phenylphenols and investigated antiproliferative effect of the QMs on three human cancer cell lines [2]. Prompted by the discovery of lead compounds with antiproliferative effect in phenylphenol series and reports on photochemical formation of naphthalene derivatives of QMs [3] we introduced hydroxyadamantyl or aminoadamantyl moiety into different positions of naphthols (1-5). Photochemistry of 1-5 was studied by preparative irradiations in the presence of nucleophiles, fluorescence, and laser flash photolysis. Antiproliferative effect of compounds was investigated with and without irradiations in vitro on three human cancer cell lines HCT 116 (colon), MCF-7 (breast), and H 460 (lung).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA