Naslov
Increased catecholamines in posttraumatic stress disorder patients change cerebral hemodynamics

Autori
Dikanović, Marinko ; Kadojić, Dragutin ; Mihaljević, Ivan ; Japundžić, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Journal of Neurology 2005 ; 12(suppl.2) / - , 2005

Skup
9th Congress of the EFNS (European Federation of Neurological Societies)

Mjesto i datum
Atena, Grčka, 17.09.2005. - 20.09.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Catecholamines; posttraumatic stress disorder; patients; cerebral hemodynamics

Sažetak
Previous investigations indicated cerebral hemodynamic changes in terms of increased mean blood flow velocities(mBFV) detected with transcranial dopler ultrasonography (TCD) in patients (pts) with posttraumatic stress disorder (PTSD). The aim of this study was to determine correlation between level of stress hormones and cerebral hemodynamic changes in PTSD pts. We examined 50 pts with acute PTSD, aged between 30 and 50 years (yrs), as well as 50 healthy subjects similar in age to control group. On the first day after hospitalization TCD was done and the measurement of vanilmandelic acid (VMA) in 24-hour urine (as metabolite of adrenalin and nor-adrenalin) were analyzed in PTSD pts. The same diagnostic procedures were repeated in PTSD pts after 21-day psychiatric treatment and in control subjects. In the first analysis 34 PTSD pts had increased mBFV, 29 of them(85.26%) had increased level of VMA. After 21-day long psychiatric treatment 9 PTSD pts had increased mBFV and 8 of them (88.88%) had increased level of VMA. The difference between two measurements was statistically significant (p < 0.01). In the control group only 2 subjects had increased mBFV while VMA was at a normal level in all subjects. The conducted research implies a correlation between increased level of stress hormones and increase in mBFV in the circle of Wiillis arteries in PTSD pts, probably caused by cerebral vasosospasm and hyperdynamic syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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