Naslov
Degree of synteny between the genomes of radiation-resistant species of Deinococcus does not reflect their extreme dsDNA break repair capabilities

Autori
Repar, Jelena ; Zahradka, Davor ; Zahradka, Ksenija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology – ISMB/ECCB 2011 / - , 2011

Skup
19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology – ISMB/ECCB 2011

Mjesto i datum
Beč, Austrija, 17.07.2011. - 19.07.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Deinococcus; DNA repair; radiation resistance; synteny

Sažetak
Deinococcus radiodurans, a highly radiation resistant bacterium, is able to accurately reassemble it's genome after it has been shattered into hundreds of pieces. Extreme radiation resistance is a typical attribute of members of Deinococcus genus implicating similar DNA repair capabilities. Such fidelity of dsDNA break repair would imply high degree of gene order conservation across genomes of deinococci. We have investigated the degree of synteny between five currently available completely sequenced genomes of genus Deinococcus. Whole genome alignments were performed by open source MUMer software implementing a suffix tree alignment algorithm. Maximal unique matching subsequences were detected for each genome pair and visualized as dot plots. Notably, the dot plot analysis revealed very low degree of synteny in all genome comparisons showing, therefore, that the ability of these deinococci to accurately reassemble DNA after extreme doses of gamma radiation is not mirrored in the degree of synteny between their genomes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA