Naslov
Heterociklički kondenzirani kinoloni i kinolini kao potencijalni antitumorski agensi
(Heterocyclic condesed quinolones and quinolines as potentional antitumor agents)

Autori
Karminski-Zamola, Grace

Izvornik
International Scientific and Professional Conference 13th Ružička days p 69

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2010

Ključne riječi
Heetrocyclic condensed quinolones; quinolines; antitumor activity
(Heterocyclic condensed quinolines; quinolones; antitumor activity)

Sažetak
A lot of condensed benzothienoquinolones, benzothienonaphthyridones and thienothienylquinolones, as well as, benzimidazo[1, 2-a]quinolines and their heterocyclic analogues diazacyclopenta[c]fluorenes were prepared in multistep synthesis:The pharmacophore groups were introduced in the main structure. Amoung the lot of prepared compounds the best antitumor activities „in vitro“ on a few human tumor cell lines showed the compounds as follows: The change of the terminal benzene nuclei of the acidic part of the molecule with thiophene in quinolones didn’t significantly influenced on the antitumor activity, while the substitution of the quinolone nulei with the naphthyridone nuclei increased antitumor activity. Quinolones and quinolines showed very similar and good antitumor activity. DNA binding reactions were detected by changes in fluorescence, UV and CD spectra.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija

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