Naslov
Pemphigoid Gestationis

Autori
Lipozenčić, Jasna ; Ljubojević, Suzana ; Bukvić-Mokos, Zrinka

Izvornik
Clinics in dermatology (0738-081X) 30 (2012), 1; 51-55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
: pemphigoid gestationis; herpes gestationis; autoimmunity; dermatoses of pregnancy; vesiculobullous disorders

Sažetak
Pemphigoid gestationis (PG) is a rare autoimmune subepidermal bullous dermatosis which occurs during pregnancy and post partum. Diagnosis is made on the basis of the presence of a subepidermal vesicle on routine histologic examination and of linear deposition of complement along the basement membrane zone of perilesional skin. The disorder is accompanied by severe pruritus and polymorphous bullous skin lesions. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence and immunoelectron microscopy tests (linear deposition of C3 with or without immunoglobulin G, along the basement membrane zone, within the lamina lucida and localized to the proximal part of anchoring filaments of the epidermal fragment of salt-split skin). Enzyme-linked immunosorbent assay for pemphigoid gestationis antibody (BP 180) commercially available. If local treatment fails, systemic corticosteroid therapy should be administered. Oral corticosteroids are the therapeutic mainstay both in pregnancy and postpartum. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Recurrence is possible during subsequent pregnancies. No significant maternal morbidity or mortality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA