Naslov
Enantiomeric Resolution with a New Chiral Stationary Phase of 7-Chloro-3-methil-3, 4-dihydro-2H-1, 2, 4- benzothiazine S, S-Dioxide, a Cognition -Enhancing Benzothiadiazine Derivative

Autori
Uzanov, D.P. ; Živković, Ilija ; Pirkle, W.H. ; Costa, E. ; Guidotti, A.

Izvornik
Journal of pharmaceutical sciences (0022-3549) 84 (1995), 8; 937-942

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HPLC resolution ; Idra 21 ; chirial stationary phase

Sažetak
The direct analytical and semipreparative high- performance liquid chromatographic (HPLC) resolution of the enantiomers of IDRA 21 is reported. IDRA 21 administered orally to rats subjected to a water maze cognition test elicited a performance enhancing effect. Between the two enantiomers (+)IDRA 21 was identified as being pharmacologically active in the water maze performance test, whereas (-)IDRA 21 was completely devoid of activity when given in doses comparable to those of the dextrorotatory (+) enantiomer. The design and preparation of the new chiral stationary phase (CSP) employed for the liquid chromatographic resolution of the enantiomers of racemic IDRA 21 is presented. This brush-type CSP, which has not been desribed before is a "mixed"(π- donor π-acceptor) type and is derived from (R)-N (3, 5-dinitrobenzoyl) allylglycine 2, 6-dimethylanilide. It is easily prepared and possesses a relatively broad scope of applicability, as determined by its ability to resolve the enantiomers of both π-acidic and π- basic components

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA