Naslov
Antitumor effect of propolis : a comparison with caffeic acid and caffeic acid phenethyl ester

Autori
Oršolić, Nada ; Horvat, Anica ; Tomašković, Ivna ; Bendelja, Krešo ; Rabatić, Sabina ; Brbot-Šaranović, Ana ; Bašić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1999 Annual Meeting of the Croatian Immunological Society / - Zagreb : Hrvatsko imunološko društvo, 1999, P12-P12

Skup
1999 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Zagreb, Hrvatska, 25.11.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Sažetak
The antitumor effect of a water soluble derivative of propolis (WSDP) caffeic acid (CA) and caffeic acid phenethyl ester (CAPE), components of natural propolis, were investigated. The oral administration of these compounds (50 mg/kg or 150 mg/kg) given before or after tumor cell inoculation supressed tumor growth of a weakly immunogeneic mammary carcinoma (MCa), singeneic to CBA mouse and enhanced the survival rate of treated annimals. The in vitro cytotoxic activity of peritoneal macrophages from treated mice to MCa, HeLa, and V79 cells, respectively was elevated. A direct relationship exists between the cytotoxic effect of CAPE or CA and the induction of DNA fragmentation and apoptosis in transformed HeLa cells, while with MCa cells that was not a case. The untransformed V79 cells were virtually resistant to apoptosis induced by either WSDP, CA or CAPE. These results suggest that antitumor effect of WSDP was mainly due its immunostimulatory properties, while it is likely that antitumor effects of CA or CAPE were mostly exibited by induction of apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA