Naslov
Environmentally-friendly organic chemistry without bulk organic solvent: mechanochemical synthesis of thioureas

Autori
Margetić, Davor ; Štrukil, Vjekoslav ; Igrc, Marina Diana ; Fábián, Lászlo ; Eckert-Maksić, Mirjana ; Friščić, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Symposium on Surface Science (ISSS-6), Abstracts / Tomi Hashizume - Tokyo : The Surface Science Society of Japan, 2011, 337-337

Skup
International Symposium on Surface Science (ISSS-6)

Mjesto i datum
Tokyo, Japan, 11.12.2011. - 15.12.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mechanochemistry; solvent free synthesis; green chemistry

Sažetak
In the search for a preparative method that would meet the requirements of green chemistry, a mechanical treatment of (in)organic reagents by simply grinding them together has reappeared as one of the solutions to pollution related issues of the modern chemical industry. Recent advancements in the solid-state synthetic methodology, such as liquid-assisted grinding (LAG), allow a simple, rapid and clean synthesis of a variety of materials, including cocrystals, salts or coordination polymers. In addition, powder X-ray diffraction (PXRD) enables the structure determination to be carried out without using solvents and the need to grow single crystals. The previously proposed „solvent-free research“ from metal-organic chemistry was extended to the field of organic synthesis. In this presentation, we report on the quantitative synthesis of structurally diverse thiourea derivatives by automatised ball-milling of the starting material. On a selection of mechanochemically prepared compounds, we have utilised PXRD for structure determination, thus implementing the „solvent-free research“ paradigm into an organic chemistry laboratory.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA