Naslov
Cytogenetic analysis of small round cell tumors

Autori
Petković, Iskra ; Ćepulić, Mlade ; Nakić, Melita ; Konja, Josip ; Stepan, Jasminka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of human genetics / ESHG - Leiden : Stockton, 2000, 89-89

Skup
32nd Annual Meeting of the ESHG

Mjesto i datum
Amsterdam, Nizozemska, 27.05.2000. - 30.05.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Small cell tumors; children; cytogenetics
(Small cell tumors; cytogenetics)

Sažetak
Small round cell tumours is a heterogenous group of diseases that include Ewing sarcoma, neuroblastoma, rhabdomyosarcoma and non-Hodgkin lymphoma. Due to similar histology tjis group of diseases is the most serious diagnostic probleme. The precise diagnosis is of particular importance since for different types of disease differing therapy is needid. The aim of this investigation is to determine the frequency and type of clonal chromosomal abnormalities in our group of children with small round cell tumors. Our investigation include 26 children aged 9 months to 15 years. Cytogenetic analysis was carried out at diagnosis and before initiating therapy. Slides were obtained from direct or short-term culture of lymph node, bone marrow or tumour pieces. Clonal chromosomal aberrations were observed in 76.9% of cases, while chromosome instability and evidence of clonal evolution were detected in 3 patients. Analysis revealed complex karyotype abnormaliuties including numerical and structural changes. The gain of some chromosome types were non-random and frequently affected chromosomes were 11, 14, 21 and X in lymphomas. Structural aberrations of chromoosme No.1 were the most frequent clonal rearrangements. This study revealed some rare chromosomal aberrations and provided additional evidence for the involvement of chromosome No.1 in neuroblastomas.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA