Naslov
Comparative in vivo lead mobilization of meso- and rac-2, 3-dimercaptosuccinic acids in albino wistar rats

Autori
Jones, Mark ; Singh, Pramod ; Kostial, Krista ; Blanuša, Maja ; Piasek, Martina ; Restek-Samaržija, Nada

Izvornik
Pharmacology & toxicology (0901-9928) 80 (1997), 4; 182-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
meso-2; 3-dimercaptosuccinic acid; racemic-2; 3-dimercaptosuccinic acid; femur; liver; kidney; brain; lead; rats

Sažetak
Comparison of the racemic and meso forms of 2, 3-dimercaptosuccinic acid (DMSA) in lead mobilization from lead-loaded albino Wistar rats demonstrates that the racemic form is significantly more effective in reducing femur lead levels. After four oral doses at 0.5 mmol/kg, femur lead levels were reduced to 87% of control values by meso-DMSA and to 50% of control levels by rac-DMSA. Similarly, when the dose was increased to 1.0 mmol/kg, femur lead levels were reduced to 69% of control levels by meso-DMSA and to 45% of control levels by rac-DMSA. A similar patern was found for renal lead levels. Brain lead concentrations were significantly lower in treated groups than in control groups, but no differences were found between rac- and meso-DMSA. Rac-DMSA is more soluble than meso-DMSA in acetonitrile, ethyl acetate, and ethyl ether. The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8. These results indicate that rac-DMSA deserves further attention as a possible substitute for meso-DMSA.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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