Naslov
Insulin-like growth factor 2 and insulin-like growth factor 2 receptor gene polymorphisms in idiopathic male infertility

Autori
Pereza, Nina ; Ostojić, Saša ; Kapović, Miljenko ; Buretić-Tomljanović, Alena

Izvornik
Journal of reproductive medicine (0024-7758) 58 (2013), 2; 132-136

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spermatogenesis; testis; genetics

Sažetak
The insulin-like growth factor 2 (IGF2) and IGF2receptor (IGF2R) have significant roles in human spermatogenesis and were previously associated with male infertility. The aim of this study was to test the association between IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms and idiopathic male infertility. Polymerase chain reaction and restriction fragment length polymorphism methods were performed to detect the IGF2 ApaI and IGF2R Gly1619Arg genotypes in 98 Croatian men with idiopathic infertility and 113 fertile men. There were no significant differences between patients and controls according to genotype (2IGF2=3.46 ; P=0.177 ; 2IGF2R=1.12 ; P=0.571) and allele frequencies (2IGF2=3.23 ; P=0.072 ; 2IGF2R=0.99 ; P=0.319). Odds ratios for recessive, dominant and codominant models, and association testing with each genotype combinations revealed no difference between infertile men and controls. In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA