Naslov
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study

Autori
Macfarlane, T.V. ; Macfarlane, G.J. ; Thakker, N.S. ; Benhamou, S. ; Bouchardy, C. ; Ahrens, W. ; Pohlabeln, H. ; Lagiou, P. ; Lagiou, A. ; Castellsague, X. ; Richiardi, L. ; Talamini, R. ; Barzan, L. ; Kjaerheim, K. ; Canova, C. ; Simonato, L. ; Conway, D.I. ; McKinney, P.A. ; Thomson, P. ; Sloan, P. ; Znaor, Ariana ; Healy, C.M. ; McCartan, B.E. ; Marron, M. ; Brennan, P.

Izvornik
Annals of oncology (0923-7534) 23 (2012), 4; 1053-1060

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aspirin use; epidemiology; gastroesophageal reflux; medical history; medication use; upper

Sažetak
The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn ; for regurgitation ; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28–0.96), hypopharynx (OR 0.53, 95% CI 0.28–1.02) and larynx (OR 0.74, 95% CI 0.54–1.01). A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA