Pregled bibliografske jedinice broj: 56289
Albumin-loaded PLA and PLGA microspheres: in vitro evaluation
Albumin-loaded PLA and PLGA microspheres: in vitro evaluation // Bollettino Chimico Farmaceutico, 138 (1999), 1; 14-18 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 56289 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Albumin-loaded PLA and PLGA microspheres: in vitro evaluation
Autori
Filipović-Grčić, Jelena ; Crc, Vlatka ; Jalšenjak, Ivan
Izvornik
Bollettino Chimico Farmaceutico (0006-6648) 138
(1999), 1;
14-18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lactic acid; PLGA; albumin; microspheres
Sažetak
Polylactide (PLA) and poly(lactide-co-glycolide) (PLGA) microspheres containing bovine serum albumin (BSA) as a model protein were prepared by an solvent extraction procedure using water-in oil-in water complex emulsion system. The effects of process parameters on morphology, particle size, protein loading and in vitro release properties of microspheres were studied. The encapsulation efficiency was very high ranging from 75% to 99%. The in vitro release profile was described as bi-phasic process with an initial burst effect and the second sustained release phase and it was dependent on the type of polymer used, and BSA loading of microspheres.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
