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Pregled bibliografske jedinice broj: 559911

Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Palada, Vinko; Terzić, Janoš; Mazzulli, Joseph; Bwala, Grace; Hagenah, Johann; Peterlin, Borut; Hung, Albert Y.; Klein, Christine; Krainc, Dimitri.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease // Neurobiology of aging, 33 (2012), 4; 836e1-836e3 doi:10.1016/j.neurobiolaging.2011.06.015 (međunarodna recenzija, članak, znanstveni)

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Naslov
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease

Autori
Palada, Vinko ; Terzić, Janoš ; Mazzulli, Joseph ; Bwala, Grace ; Hagenah, Johann ; Peterlin, Borut ; Hung, Albert Y. ; Klein, Christine ; Krainc, Dimitri.

Izvornik
Neurobiology of aging (0197-4580) 33 (2012), 4; 836e1-836e3

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Parkinson's disease; Parkinsonism; Histamine; HNMT; Association studies in genetics

Sažetak
Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (χ(2) = 11.65 ; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Genetic Reports Abstracts



POVEZANOST RADA

Projekti:
216-0000000-3348 - ULOGA UPALNIH PROCESA U NASTANKU MALIGNIH TUMORA (Terzić, Janoš, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Janoš Terzić (autor)

Avatar Url Dimitri Krainc (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.neurobiologyofaging.org dx.doi.org

Citiraj ovu publikaciju:

Palada, Vinko; Terzić, Janoš; Mazzulli, Joseph; Bwala, Grace; Hagenah, Johann; Peterlin, Borut; Hung, Albert Y.; Klein, Christine; Krainc, Dimitri.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease // Neurobiology of aging, 33 (2012), 4; 836e1-836e3 doi:10.1016/j.neurobiolaging.2011.06.015 (međunarodna recenzija, članak, znanstveni)
Palada, V., Terzić, J., Mazzulli, J., Bwala, G., Hagenah, J., Peterlin, B., Hung, A., Klein, C. & Krainc, D. (2012) Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiology of aging, 33 (4), 836e1-836e3 doi:10.1016/j.neurobiolaging.2011.06.015.
@article{article, author = {Palada, Vinko and Terzi\'{c}, Jano\v{s} and Mazzulli, Joseph and Bwala, Grace and Hagenah, Johann and Peterlin, Borut and Hung, Albert Y. and Klein, Christine and Krainc, Dimitri.}, year = {2012}, pages = {836e1-836e3}, DOI = {10.1016/j.neurobiolaging.2011.06.015}, keywords = {Parkinson's disease, Parkinsonism, Histamine, HNMT, Association studies in genetics}, journal = {Neurobiology of aging}, doi = {10.1016/j.neurobiolaging.2011.06.015}, volume = {33}, number = {4}, issn = {0197-4580}, title = {Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease}, keyword = {Parkinson's disease, Parkinsonism, Histamine, HNMT, Association studies in genetics} }
@article{article, author = {Palada, Vinko and Terzi\'{c}, Jano\v{s} and Mazzulli, Joseph and Bwala, Grace and Hagenah, Johann and Peterlin, Borut and Hung, Albert Y. and Klein, Christine and Krainc, Dimitri.}, year = {2012}, pages = {836e1-836e3}, DOI = {10.1016/j.neurobiolaging.2011.06.015}, keywords = {Parkinson's disease, Parkinsonism, Histamine, HNMT, Association studies in genetics}, journal = {Neurobiology of aging}, doi = {10.1016/j.neurobiolaging.2011.06.015}, volume = {33}, number = {4}, issn = {0197-4580}, title = {Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease}, keyword = {Parkinson's disease, Parkinsonism, Histamine, HNMT, Association studies in genetics} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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