Naslov
Environmental radon daughters reveal pathognomonic changes in the brain proteins and lipids in patients with Alzheimer's Disease and Parkinson's Disease, and cigarette smokers
(Environmental radon daughters reveal pathognomonic changes in the brain proteins and lipids in patients with Alzheimer's Disease , Parkinson's Disease, and cigarette smokers)

Autori
Momčilović, Berislav ; AlKhatib, H.A ; Duerre, J.A ; . Cooley, M.A ; . Long, W.M ; Harris R.T ; Lykken G.I.

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 50 (1999), 4; 347-369

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cell membrane impairment; chlorine hypothesis; radiochemical injury; systemic brain disease

Sažetak
This paper presents an investigation of the retention of environmental radon daughters 210Po (alpha particle emitting radio-nuclide), and 210Bi (beta particle emitting radio-nuclide), in lipid and protein fractions of the cortical grey and subcortical white matter from the frontal and temporal brain lobes of patients who suffered from Alzheimer's disease and Parkinson's disease, of cigarette smokers, and of control subjects. 210Po and 210Bi radioactivity increased tenfold in the cortical grey and subcortical white protein fraction in patients with Alzheimer's disease and smokers, and tenfold in the cortical grey and subcortical white lipid frcation in patients with Parkinson's disese. Free radicals generated by radon daughtersmay add to the severity of the radio-chemical injury to the brain astrocytes. The pathognomonic distribution of radon daughters to čipids in patients with Parkinson's disese and to proteins in patients with Alzheimer's disease was attributed to high chlorine affinity of radon daughters. The changes in the membrane protein pores, channels, and gates in patients with Alzheimer's disease and in the lipid bilayer in patients with Parkinson's disease are at the core of what the authors think are two systemic brain diseases,

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA