Naslov
Interspecies differences in PSA-NCAM zones in adult fish brain

Autori
Labak, Irena ; Viljetić, Barbara ; Majić, Senka ; Heffer, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
SiNAPSA Neuroscience Conference SNC'11, Book of Abstracts / Damjan Osredkar, Blaž Koritnik, Miha Pelko (ur.) - Ljubljana : Slovenian Neuroscience Association (SiNAPSA), 2011, 148-148

ISBN
978-961-91704-4-1

Skup
Sinapsa Neuroscience Conference '11 Central European FENS Featured Regional Meeting

Mjesto i datum
Ljubljana, Slovenija, 22.09.2011. - 25.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PSA-NCAM; migration; regeneration; fish brain

Sažetak
The neural cell adhesion molecule (NCAM) plays important role in adult neurogenesis, survival and migration of neuronal steam cells. Reversible attachment of polysialc acid (PSA) to extra cellular domain of NCAM promotes migration which is limited to rostral olfactory stream in the adult brain of mammals. Non-mammalian vertebrates poses much higher potential for regeneration due to constitutive adult neurogenesis, apoptotic elimination of damaged cells and efficient migration, differentiation and integration of newly derived cells in existing neural network. We compared expression of PSA-NCAM in sturgeon (Acipenser ruthenus), carp (Cyprinus carpio), trout (Salmo gairdneri), catfish (Silurus glanis), perch (Perca fluviatilis) and pike (Esox lucius) brains with two different antibodies (mAb735 and clone 2-2B). PSA-NCAM zones in carp, trout and perch brain extend from telencephalon into cerebellum and mesencephalon. From the level of rostral mesencephalon toward spinal cord extensive PSA-NCAM zone exist in sturgeon and pike brain. While two antibodies give similar result on trout and pike brains, reactivity of mAb735 is limited to cerebellar proliferation zone in perch and carp. Also, carp and catfish brain, contrary to others, have proliferative zones in facial and vagal lobes - enlargement of nucleus solitarius connected with taste system and specialized palatal organ. PSA-NCAM is just one of the markers that are indicating potential for regeneration, but its expression in rhombencephalon and spinal cord of sturgeon and pike could be promising for spinal cord injury studies.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA