Naslov
Rekombinogenost i Distribucija Palindroma u Genomu Kvasca <i>Saccharomyces cerevisiae<i>
(Recombinogenicity and Distribution of Palindromes in the Yeast <i>Saccharomyces cerevisiae<i> Genome)

Autori
Lisnić, Berislav

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija

Fakultet
Prirodoslvno-matematički fakultet

Mjesto
Zagreb

Datum
06.09

Godina
2011

Stranica
64

Mentor
Svetec, Ivan Krešimir

Ključne riječi
cruciform/genome stability/palindrome/recombination/yeast

Sažetak
Genomes of many organisms, from bacteria to mammals, are known to contain significant proportion of palindromic sequences. Although frequently located in <i>cis</i>-acting genetic elements, where they play an important role in the regulation of various cellular processes, palindromes have been recognized as recombinogenic motifs that can provoke various types of genome rearrangements and cause genetic diseases in humans. Employing yeast <i>Saccharomyces cerevisiae</i> as a model organism, this study provides systematic analysis of factors affecting palindrome-stimulated recombination, together with computational tools for distribution analysis of palindromes in DNA sequences. This work establishes for the first time that palindromic sequences become recombinogenic only after they attain a critical length of approximately 70 bp. In addition, the obtained results not only indicate that palindromes conform to specific rules of evolutionary dynamics, but also suggest the existence of a mechanism that suppresses the recombinogenicity of numerous palindromes longer than 70 bp present in the human genome.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija

POVEZANOST RADA