Pregled bibliografske jedinice broj: 557473
NADPH and Iron may have an important role in attenuated mucosal defense in Helicobacter pylori infection?
NADPH and Iron may have an important role in attenuated mucosal defense in Helicobacter pylori infection? // Mini-Reviews in Medicinal Chemistry, 10 (2010), 1309-1315 doi:10.2174/138955710793564160 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 557473 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
NADPH and Iron may have an important role in attenuated mucosal defense in Helicobacter pylori infection?
Autori
Dovhanj, Jasna ; Kljaić, K. ; Smolić, Martina ; Švagelj, Dražen
Izvornik
Mini-Reviews in Medicinal Chemistry (1389-5575) 10
(2010);
1309-1315
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Free radicals; Helicobacter pylori; Iron; NADPH
Sažetak
Host intracellular iron has been recognized as an important cofactor in induction of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidative burst as antimicrobial defense mechanism. It is plausible that iron chelator directly inactivates NADPH oxidase by chelating the active site heme iron of flavocytochrome b558 thus blocking the transfer of electrons from NADPH to oxygen and its reduction to superoxide anion. Thus, altering the equilibrium of intracellular iron could influence the course of infection to the enhancement of the pathogen with regard to oxidative stress.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
219-2192382-2386 - Razvoj modela funkcije cirkulacijskog sustava ovisnog o arterijskoj elastičnosti (Marić, Svjetlana, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- MEDLINE
