Naslov
Heart Rate, Insulin Resistance, Obesity and Blood Pressure in Croatian Rural Population

Autori
Karanović, Sandra ; Vuković Lela, Ivana ; Dika, Živka ; Pećin, Ivan ; Cvitković, Ante ; Bitunjac, Milan ; Fuček, Mirjana ; Kos, Jelena ; Abramović, Mirta ; Jurić, Dragana ; Sertić, Jadranka ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Kidney Blood Press Res 2011 ; 35 / - , 2011, 89-105

Skup
6th Central European Meeting on Hypertension

Mjesto i datum
Bratislava, Slovačka, 22.10.2011. - 25.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Heart Rate ; Insulin Resistance ; Obesity ; Blood pressure

Sažetak
Aim: To investigate the relation of increased sympathetic tone (heart rate), insulin resistance, overweight and blood pressure (BP) in the general rural population. Design and Method: Of 1, 289 subjects enrolled in a cross sectional survey, 272 participants (118 men, 154 women, median age 51 years, range 18–87) were included into this analysis. BP and heart rate (HR) were measured 3 times in the sitting position with an OMRON M6 device. Body mass index (BMI) and waist circumference (WC) were determined. Fasting blood glucose and insulin were determined. HOMA index was used to calculate insulin resistance (IR). Subjects were divided into three groups: normal BP (< 130/85 ; n = 113) (NBP), prehypertension (130/85– 139/89 ; n = 25) (PH), and untreated hypertension (" 140/90 ; n = 65) (HT). Kruskal- Wallis, Mann Whitney, and Spearman correlation tests were used. Significance was set at 0.05. Results: There were no differences in age between the groups. An increasing trend in all of the measured variables was found among the 3 groups. Significant differences in BMI were observed between NBP vs. PHT and HT (p < 0.001) ; furthermore a significance was found in WC and HOMA index between NBP and HT. HR did not differ significantly between the three groups. Systolic and diastolic BP were found to significantly correlate with BMI, WC and HOMA index (p < 0.0001 ; p < 0.004), but not with HR (p = 0.667).However, HR correlated significantly with HOMA index (r=0.250 ; p < 0.0001). A significant correlation between HOMA index and BP was observed as well (r=0.225 ; p = 0.0002 for systolic BP ; r=0.239 ; p = 0.0001 for diastolic BP). Conclusion: BP is strongly related with BMI, WC and insulin resistance. A direct relation between BP, BMI, WC and sympathetic tone (HR) was not found, but a trend of increasing HR among the BP groups was observed. The positive correlation between HR and HOMA index might suggest on a common mechanism involved in both conditions. These preliminary results are encouraging.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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