Naslov
Metabolic syndrome and early kidney damage in rural population

Autori
Vuković Lela, Ivana ; Karanović, Sandra ; Čapkun, Vesna ; Pećin, Ivan ; Miletić-Medved, Marica ; Čvorišćec, Dubravka ; Sertić, Jadranka ; Cvitković, Ante ; Bitunjac, Milan ; Reiner, Željko ; Kuzmanić, Duško ; Jurić, Dragana ; Premužić, Vedran ; Jelaković, Bojan.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Hypertension Vol 28, e-Supplement A, June 2010 / - , 2010, Xx-xx

Skup
20th European Meeting on Hypertension

Mjesto i datum
Oslo, Norveška, 18.06.2010. - 21.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metabolic syndrome ; kidney damage

Sažetak
Objective: To analyze prevalence of metabolic syndrome (MS) in early phases of chronic kidney disease (CKD) and effect of its components on early renal impairment. Design and Method: In this survey 1003 farmers from continental, rural part of Croatia were enrolled (386 men ; 617 women ; average age 52(30-95) ; females were older(Mann-Whitney test:z¼3, 6 ; p<0, 001). After extended questionnaire and clinical exam, fasting blood was drawn and second morning urine sample was collected (for microalbuminuria (MA) and alpha1 microglobulinuria (a1MG). Blood pressure (BP) was measured following the ESH/ESC guidelinies, metabolic syndrome (MS) was defined according to the NCEP ATP III recommendations. Subjects were classified into theCKD stages groups according to the KDOQI classification. Results: In general rural population prevalence of MS was 22, 6% (30% men, 70% women ; p¼0, 045). Prevalence of MS was significantly higher in subjects with CKD stage 3 as compared to the CKD stage 1 (x2¼4 ; p¼0, 045) as well as in subjects with MA compared to those with normal values (x2¼5, 85 ; p¼0, 016), while there was no difference between subjects with elevated and normal values of a1MG (x2¼0, 19 ; p¼0, 662). We observed significant difference between stages CKD 1 and 3 in BP (x2¼15, 6 ; p<0, 001), waist circumference (WC) (x2¼26, 8 ; p<0, 001), fasting blood glucose (FBG) (x2¼22 ; p<0, 001), triglycerdies (TG) (x2¼7, 4 ; p¼0, 024) and HDL level (x2¼0, 621 ; p<0, 001). Significant differences in BP, FBG, WC and TG were observed between subjects with MA in comparison with normal values (x2¼8, 1 ; p¼0, 004 ; x2¼23, 2 ; p<0, 001 ; x2¼6, 85 ; p¼0, 009 ; x2¼9, 0 ; p¼0, 003, respectively). Multivariate age-adjusted OR for development of MA was significant for FBG and TG (OR 2(1, 43–2, 8) ; p<0, 001 ; OR 1, 59(1, 02– 2, 5) ; p¼0, 043, respectively). Only systolic BP was significantly associated with a1MG(x2¼2, 59 ; p<0, 001) with multivariate age-adjusted OR for development of a1MG of 1, 52 (1, 01–2, 28) ; p¼0, 043. Conclusions: Prevalence of MS and its components increase with CKD stage. MS, and especially FBG and TG are risk factors for MA while systolic BP is a risk factor for proximal tubule damage i.e. a1MG.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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