Naslov
Metabolic characteristics and heart rate of newly diagnosed non-treated hypertensive, prehypertensive and normotensive subjects

Autori
Karanović, Sandra ; Jurić, Dragana ; Juras, Josip ; Čapkun , Vesna ; Dika, Živka ; Vuković Lela, Ivana ; Fištrek, Margareta ; Kos , Jelena ; Laganović, Mario ; Cvitković, Ante ; Premužić, Vedran ; Pećin, Ivan ; Bitunjac, Milan ; Leko , Ninoslav ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Hypertension Vol 29, e-Supplement A, June 2011 / - , 2011, E299-e299

Skup
21st European Meeting on Hypertension and Cardiovascular Prevention

Mjesto i datum
Milano, Italija, 17.06.2011. - 20.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
heart rate ; metabolic syndrome

Sažetak
Objective: Both the metabolic abnormalities and a faster heart rate are recognized cardiovascular risk factors and both are associated with hypertension. However, it is still matter of debate whether the high risk profile is also present in prehypertension (PH). Our aim was to analyse presence of these additional risk factors in newly diagnosed non-treated hypertension (HT) and PH. Design and Method: Out of 1181 subjects enrolled in population based cohort study conducted in Croatian rural area, 203 participants (65 men, 138 women, mean age 50.7 years, range 19- 87) had all the laboratory and clinical data and were included in this report. We also excluded eligible subjects if they had an acute illness, chronic terminal disease, pregnancy, treated HT, diabetes, arrhythmias, dementia, immobility and if taking NSAID or corticosteroids. Blood pressure (BP) and HR were measured 3 times in a sitting position with OMRON M6 device. Body mass index (BMI) and waist circumference (WC) were determined. Fasting blood was analysed for glucose (FBG), insulin, total cholesterol (T-C), HDL, LDL, triglycerides (TG), haematocrite, C reactive protein (CRP), white blood cell (WBC) and neutrophil count. HOMA index was used to calculate insulin resistance (IR). Subjects were divided in three groups: optimal BP (< 120/80 ; N = 59) (OBP), PH (120/80-139/89 ; N = 79), and HT ( 140/90 ; N = 65). ANOVA, Kruskal-Wallis, post hoc (Tuckey, Mann Whitney) and Spearman’s correlation test were used. Significance was set at 0.05. Results: There were no differences in age between groups. IR prevalence increased from OBP to PH and HT (33.8%, 51.9%, 67.6%, respectively). Differences were significant between OBP vs. PH and HT (p = 0.035, p < 0.001, respectively), but not between PH and HT (p = 0.057). We found significant correlation between IR, systolic, diastolic BP, and HR (r = 0.22 ; 0.29 ; 0.24, respectively ; p < 0.001). HT patients and PH subjects with IR had significantly higher values of BMI, WC, insulin, T-C, LDL-C, TG than those without IR (p < 0.001). Even OBP subjects with IR had significantly higher BMI, WC, insulin, TG and lower HDL values than ones without IR(p < 0.001). In all groups HR was higher in subjects with IR. Values on CRP and WBC will be presented separately. Conclusions: Observed high prevalence of IR, metabolic syndrome and faster heart rate in OBP and PH groups call for life style modification in general population, or at least in those with IR. Individuals with metabolic syndrome and tachycardia should be followed closely and considered for drug therapy if they failed to respond to life style modification. Correlation between IR and HR (starting from OBP) in this study suggests that a common mechanism - sympathetic overactivity- may be involved in both conditions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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