Naslov
The biological role of NKG2D in innate immunity

Autori
Polić, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of the 16th FEBS Summer School on Immunology: "Genes, Receptors and Regulation / - , 2011

Skup
16th FEBS Summer School on Immunology: "Genes, Receptors and Regulation"

Mjesto i datum
Hvar, Hrvatska, 03.09.2011. - 11.09.2011

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NKG2D; NK cells; gd T cells; MCMV; IgE; atopy

Sažetak
NKG2D is one of the most intensively studied immune receptors in the past decade. Its unique binding and signaling properties, expression pattern and functions have been attracting much interest within the field due to its potent anti-viral and anti-tumor properties. As a potent activating receptor, NKG2D is expressed on cells of the innate and adaptive immune system. It recognizes stress induced MHC class I-like ligands and acts as a molecular sensor for cells jeopardized by viral infections or DNA-damage. Recent analyses of NKG2D-deficient mice confirmed important role of NKG2D in exerting effector functions (cytotoxicity, cytokine production) of the innate immune system, but also revealed some new biological functions of this molecule on NK and  T cells. NKG2D plays a regulatory role in the development of NK cells. We observed following consequences of NKG2D-deficiency on these cells: a) faster division and differentiation of NK cells ; b) perturbation in size of NK cell subpopulations and, c) their augmented sensitivity to apoptosis. NKG2D-/- mice also showed an enhanced NK cell-mediated resistance to MCMV infection which is a consequence of NK cell dysregulation. Epidermal  T cells play important role in tumor surveillance and maintenance of epidermal epithelial cells and these processes are largely NKG2D-dependent. However, the systemic implications of this lymphoid stress-surveillance response are unknown. Our recent analyses have shown that NKG2D-mediated epidermal stress-surveillance in combination with an epidermally applied antigen is responsible for triggering of a systemic and specific IgE response, which has important clinical implications.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA