Pregled bibliografske jedinice broj: 556735
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform // Science, 289 (2000), 5485; 1751-1754 doi:10.1126/science.289.5485.1751 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 556735 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform
Autori
Mulac-Jeričević, Biserka ; Mullinax, Robert A. ; DeMaylor, Francesco J. ; Lydon, John P. ; Conneely, Orla M.
Izvornik
Science (0036-8075) 289
(2000), 5485;
1751-1754
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
progesterone receptor-A ; and progesterone receptor-B ; knockout
Sažetak
Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR- A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
