Naslov
ACE I/D polimorfizam u zloćudnim bolestima pluća
(ACE I/D polymorphism in lung malignancy)

Autori
Sanja Dević ; Veljko Flego ; Smiljana Ristić ; Miljenko Kapović ; Anđelka Radojčić Badovinac

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Seventh ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine ; Final program and Abstracts / Schanfield, Moses ; Primorac, Dragan ; Vuk-Pavlović, Stanimir (ur.). / - Zagreb : International Society for Applied Biological Sciences (ISABS), 2011

Skup
PETI HRVATSKI KONGRES IZ HUMANE GENETIKE

Mjesto i datum
Bol, Hrvatska, 20.06.2011. - 22.06.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ACE I/D polimorfizam; karcinom pluća; drugi primarni karcinom; pojavnost karcinoma; genetika
(ACE I/D polymorphism; lung cancer; second primary malignancy; cancer susceptibility; genetics)

Sažetak
Objective: Angiotensin converting enzyme (ACE) plays an important role in cardiovascular homeostasis and inflammation processes. Its plasma levels depend on the insertion/deletion (I/D) polymorphism so that homozygotes for the I allele have the lowest, and homozygotes for the D allele the highest plasma levels. It has been shown that ACE II genotype positively correlates with cell survival thus increasing malignancy. Moreover, it has been found that patients with lung cancer have decreased ACE plasma levels. We investigated whether ACE I/D polymorphism genotype distribution differs between patients with primary lung cancer and patients with lung malignancy as a second primary cancer. Methods: 201 patients with primary lung carcinoma as first malignancy and 107 patients with second primary lung carcinoma were included in this study. ACE I/D genotypes were determined by polymerase chain reaction. Results: Genotype distribution and allelic frequencies between patients with primary lung cancer and patients with second primary lung cancer were significantly different (ACE II genotype 16.4% vs. 29.0%, p=0.009 ; ACE I allele 41.0% vs. 51.9%, p=0.010). Conclusions: Results suggest that the II genotype and the I allele could be risk factors for developing second primary lung carcinoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA