Naslov
The influence of NK, NKT and Tregs in the activation of the innate immune response following burn injuries

Autori
Mrakovčić-Šutić, I ; Pirjavec-Mahić, A

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / Rudolf Valenta - Beč : Austrian Society for allergology and Immunology, 2010

Skup
Annual Meeting of the Austrian Society for Allergology and Immunology in co-operation with the national Societies of Croatia, Czech Republic, Hngary, Slovakia and Slovennia

Mjesto i datum
Beč, Austrija, 03.12.2010. - 05.12.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
burn injuries; innate immunity; NKT cells; Tregs

Sažetak
Introduction: burn injuries represent a significant public health risk and are often associated with a life-threatening systemic inflammatory response, inducing accelerated lymphocyte apoptosis in reconvalescent period. Cytotoxic T cells (CTL) and natural killer (NK) cells have the possibility to induce cell death of neoplastic and/or altered-self cells by two distinct lytic pathways: releasing of perforin and granzymes or by the surface interaction between Fas ligand and Fas. NKT cells are very important in the regulation of antimicrobial, antitumor, autoimmune and allergic immune defence and together with regulatorx T cells (Tregs) represent carries of innate immunity, playing a crucial role in the control of impaired immune responses. Tregs may suppress multiple cell types involved in inflammatory and immune response. In this study, we report a critical requirement for NKT and regulatory T cells (Tregs), in the immune dysfunction that occurs after burns. Methods: Human peripheral blood mononuclear cells (PBMNC) from patients with severe burn injuries and healthy volunteers were taken and analyzed using intracellular and surface immunofluoresecncy (FACSCalibur). Statistical analysis was done in computer program Statistica 7.1 (StatSoft, Inc., Tulsa, OK, USA). Results: Tregs and NKT cells were significantly decreased in patients with burn injuries and is comparable with the level of the disorders. Conclusion: Tregs and NKT monitoring may contribute to better treatment of patients suffering from burn injuries and pain, contributing to faster recovery and/or reducing infections in all conditions characterized by impaired organism resistance.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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