Naslov
Bulozna oralna erupcija uzrokovana azitomicinom
(Bullous oral eruptions caused by azithromycin)

Autori
Lončar, Božana ; Mravak-Stipetić, Marinka ; Skerlev, Mihael ; Baričević, Marinka ; Makar Aušperger, Ksenija

Izvornik
Acta stomatologica Croatica (0001-7019) 45 (2011), 2; 120-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
oralna sluznica; bulozna erupcija; azitromicin; oralna reakcija na lijek
(oral mucosa; oral bullous eruption; azitromycin; oral adverse drug reaction)

Sažetak
Macrolides are considered the safest group of antibiotics, with a very low prevalence of allergic reactions (0.4-3%). We present a case report of a young patient who developed bullous eruption on buccal mucosa and lips after ingestion of the third dose of azithromycin. After taking steroid therapy the lesions started to regress, but on the fourth day a new bullous eruption appeared on labial mucosa with lower intensity. This could be explained by the fact that azithromycin has a long plasma half-life and is detectable in neutrophil lysates 28 days after the last dose, which may be related to a higher risk of adverse effects. According to our knowledge and from the available literature. This is the first described case of oral eruption after azithromycin treatment. In spite of the fact that azithromycin remains one of the best tolerated macrolides, potentially severe adverse reactions may sometimes occur.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA