Naslov
Chorionic villus sampling after the first trimester.

Autori
Podobnik, Mario ; Ciglar, Srećko ; Podgajski, Mario ; Gebauer, Beata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
16. FIGO World Congress of Gynecology and Obstetrics Book of Abstracts / - Washington (MD), 2000

Skup
16. FIGO World Congress of Gynecology and Obstetrics

Mjesto i datum
Washington D.C., Sjedinjene Američke Države, 03.09.2000. - 09.09.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
late CVS; ultrasound; prenatal diagnosis

Sažetak
Objectives The purpose of this article was to evaluate the association between late CVS (placental biopsy) and complications between sampling and delivery. Study Methods Late chorionic villus sampling under ultrasound guidance was carried out in 2600 (86,7 %) cases in the second trimester and 400 (13,3 %) cases in the third trimester of pregnancy. Out of 3000 late CVS, 684 (22,8 %) were performed because of suspicious ultrasonographic findings. In the 500 patients between 13 and 16 weeks of gestation color Doppler was used to investigate the uteroplacental and fetal vessels before and after late chorionic villus sampling. Results In 24 patients (0,8 %), complications between sampling and delivery were found. There were only nine (0,35 %) spontaneous abortions four to six weeks after late chorionic villus sampling. We found 156 (5,2 %) chromosomal abnormalities. In the group with suspicious ultrasonic findings (684 cases) we found significant oligohydramnios in 300 (43,8 %) and significant polyhydramnios in 150 (21,9 %), and 105 (15,4 %) had chromosomal abnormalities. Among the 156 patients with chromosomal abnormalities, ultrasonographic findings in 85 (54,4 %) were detected after 20th week of pregnancy. There were no significant differences in mean pulsatility indices between uteroplacental and fetal vessels before and after late chorionic villus sampling. Preliminary data for twenty trisomic fetuses indicate an abnormally increased umbilical PI and abnormally decreased middle cerebral artery PI. Conclusions Late CVS is a safe method of prenatal diagnosis for high-risk couples and does not significantly affect the outcome of pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA