Naslov
Genotoxic impact of coke oven plant pollution

Autori
Brumen, Vlatka ; Franekić, Jasna ; Horvat, Đurđa ; Tonković, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the XXXVII European Congress of Toxicology / Alexander, J. ; Tahti, H. ; Seiler, J.P. - Amsterdam : Elsevier, 1999

Skup
EUROTOX 99

Mjesto i datum
Oslo, Norveška, 27.06.1999. - 30.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
coke oven plant pollutants; chromosomal aberrations

Sažetak
The study was aimed at assessing the genotoxic impact of coke oven plant pollutants via mutagenic monitoring of occupationally and ambientally exposed persons. The exact concentration of main air chemopollutants, such as smoke, polycyclic aromatic hydrocarbons, carbon monoxide, sulfur dioxide, cyanides, phenol, ammonia, benzene, xylene and hydrogen sulfide were measured using referent methods recommended by WHO. The mutagenic monitoring comprised 92 examines, divided into three groups; 32 coke plant employees, 20 coke oven area inhabitants and 40 controls. All underwent standard cytogenetic examinations, including conventional structural chromosomal aberration analysis, sister chromatid exchange method and micronucleus test. The results revealed the level of air pollution both in the work environment and in the coke oven area to be markedly elevated and mostly surpassing the maximal permissible one for the particular compound, as prescribed by the current Croatian laws. Statistical analysis revealed significant differences in a chromosomal damage incidence between the occupationally and ambientally exposed groups when compared to the controls (p<0.05). Thereby chromosomal aberrations occurring significantly more frequently in coke plant workers than in coke oven area dwellers (p<0.05). The same goes for the incidence of single- and double-strain breaks and acentrics. Dicentric chromosomes were also significantly more frequent in the exposed groups than in controls, but the difference in their incidence among coke plant employees and among coke oven area dwellers was insignificant (p>0.05). The outcome of this study strongly suggests the necessity for setting rigorous criteria when choosing preferences among the available energy sources.

Izvorni jezik
Engleski

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