Naslov
Botulinum toxin A in experimental migraine

Autori
Lacković, Zdravko ; Filipović, Boris ; Matak, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Acta Clinica Croatica, Vol. 49 No. Supplement 2 Lipanj 2010 / Kusić, Zvonko - Zagreb, 2010, 87-88

Skup
50th International Neuropsychiatric Pula Congresses

Mjesto i datum
Pula, Hrvatska, 16.06.2010. - 19.06.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
botulinum toxine type A; migraine; neurogenic inflammation

Sažetak
Introduction/Objectives: Control studies in humans indicate that botulinum toxin type A (BoNT/A) alleviates symptoms of migraine. However, this problem was not investigated in details in experimental animals. Infraorbital nerve constriction injury is a model used both in trigeminal neuropatic pain and in migraine. We have assessed mechanical allodynia and dural extravasation in this model after single unilateral injection of BoNT/A (3.5 U/kg). Participants, Materials/Methods: Neuropathic behavior in rats was induced by a chronic constriction injury of the infraorbital nerve, and BoNT/A was administered into whisker pad either ipsilaterally or contralaterally to the side of nerve injury. The effects of BoNT/A on bilateral pain were assessed for a period of a month by measuring mechanical allodynia with Von Frey filaments. Animals which developed mechanical allodynia were administered with Evans blue intravenously and dural extravasation of Evans blue - plasma protein complexes was assessed. Results: Both mechanical allodynia and dural extravasation were reduced by a single unilateral BoNT/A (3.5 U/kg) injection on the side of the toxin injection, and on the opposite side, as well. Conclusions: Both migraine signs: pain and dural extravasation were reduced after BoNT/A injection. For the fi rst time we show presence of dural extravasation after infraorbital nerve constriction injury. Bilateral antinociceptive eff ect and even more reduction of dural extravasation suggests a central mechanism of BoNT/A actions

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA